CHOP research offers insights into epilepsy site

CHOP research offers insights into epilepsy, schizophrenia, other neuropsych disorders Medical researchers have manipulated human stem cells into producing types of brain cells recognized to play important roles in neurodevelopmental disorders such as epilepsy, autism and schizophrenia site . The brand new model cell system allows neuroscientists to investigate normal brain development, as well as to identify specific disruptions in biological signals that may donate to neuropsychiatric diseases. Scientists from The Children's Hospital of Philadelphia and the Sloan-Kettering Institute for Malignancy Research led a report group that described their study in the journal Cell Stem Cell, published online today.

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The research, performed in cell pets and cultures, focused on a kind of astrocytoma, the most typical type of mind tumor in children. When surgeons can completely remove an astrocytoma , a child can be cured. However, many astrocytomas are as well widespread or in too delicate a niche site to be safely removed. Others might recur. So pediatric oncologists have already been seeking better options—preferably, a drug that may selectively and definitively eliminate the tumor with low toxicity to healthy cells. The current study targets mutations in the BRAF gene, probably the most commonly mutated genes in human being cancers.

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