The new donor bone marrow must match the genetic makeup of the patient s own bone marrow.

The new donor bone marrow must match the genetic makeup of the patient ‘s own bone marrow. If the donor bone marrow is not perfectly matched, as is often the case, it can perceive the patient’s body as foreign material to be attacked and destroyed. This condition, known as GVHD, is often life-threatening and limits the use of allogeneic bone marrow transplantation.

Bz-423 has a much higher selectivity to silence disease-causing cells than with the immunosuppressants seen typically used for diseases like GVHD, Glick said, described in the experiments in the paper, Bz-423 in mice arrested GVHD selective killing of pathogenic T cells, without adverse effects on the normal cells or bone marrow transplant success.####Reference: Deng LH, Q Xia Yang XN, Effect the admission existing hypertriglyceridemia in the consequences of severe acute pancreatitis. World J Gastroenterol 2008; 14 :4558-4561.

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